Lab news

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2019

NOVEMBER 2019: Payne lab goes SkyHigh! Grateful to work with such a talented and committed team. Wishing Jinmin Lee farewell and good luck as she starts her new position as a Senior Scientist at Cabaletta Bio

OCTOBER 2019:

Carolyn and Napatra’s paper on factors predictive of complete remission after rituximab therapy for pemphigus is published in JAMA Dermatology. Thanks to JAMA Dermatology for their podcast featuring our article

Congratulations to Sangwook for his plenary presentation on MuSK CAAR T cells for myasthenia gravis at the American Neurological Association meeting in St. Louis, which was highlighted as a featured abstract

SEPTEMBER 2019:

DSG3-CAART IND receives FDA clearance to initiate the first-in-human DesCAARTes trial in mucosal pemphigus vulgaris! The Payne lab is proud and grateful to have worked with the experienced Penn/CHOP teams that supported the IND, in alliance with Cabaletta Bio. Many thanks to the Penn/CHOP teams including preclinical (Milone/Fraietta labs, vet school Comparative Pathology Core, Stem Cell and Xenograft Core), manufacturing (Cell and Vaccine Production Facility, CHOP vector core), clinical/regulatory (Center for Cellular Immunotherapies, Translational Correlative Studies Laboratory, plus the DesCAARTes investigators David Porter/Rob Micheletti/Victoria Werth/Noelle Frey/Elizabeth Hexner, Daniel Shin). We are also thankful for the support from offices throughout Penn who helped us to usher this technology from the bench to the clinic (Penn Center for Innovation, Office of General Counsel, Office of Clinical Research, Penn Center for Precision Medicine, Institute for Immunology).

Christoph and Daniel’s review on genetically engineered therapies for autoimmunity is published in Current Opinions in Immunology

JUNE 2019: Farewell and best wishes to visiting scholar Napatra Tovanabutra, MD, who will be returning to his faculty position at Chiang Mai University, Thailand

American Neurological Association highlights abstracts to be presented at 144th Annual Meeting: Advances lead to a more complete picture of precision medicine Newswise, Sep 2019

MAY 2019: Welcome to Ellyssa Sherman, a master’s student at Thomas Jefferson University, who will be completing her thesis on B cell tolerance checkpoints in pemphigus vulgaris

Establishment of the Penn Clinical Autoimmunity Center of Excellence, funded by NIAID. Aimee is proud to be working with Amit Bar-Or, MD, and Nina Luning Prak, MD, PhD, to investigate B cells as drivers of autoimmunity in a broad range of autoimmune diseases. Thanks to Knowledge@Wharton SiriusXM Channel 132 and the Daily Pennsylvanian for featuring our new center.

MARCH 2019: Christoph delivers the Quo Vadis Lecture at the ADF meeting in Munich

JANUARY 2019: Payne lab welcomes Insuk Choe, JD, who will coordinate our Clinical Autoimmunity Center of Excellence and Canine CAAR Club (3C) programs on campus

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